This document consists of two parts:
Methodological part (section 1), containing the template of Core protocol for AEG. This template defines which protocol items are essential to set up a common or coordinated AEG study (“core” items) and contains advice on how to fill them-in.
First EUnetHTA pilot of a joint AEG recommendation (section 2). This pilot aimed at testing multi-agency collaboration in agreeing on a research question and core items of a study protocol to generate additional evidence for renal denervation, on the basis of evidence gaps identified in EUnetHTA’s rapid assessment of this technology. Study funding or implementation were not within scope of this exercise.